Friday, August 31, 2012

50GB free Dropbox service confirmed for Samsung Galaxy Note II and Galaxy Camera

Free Dropbox services confirmed for Samsung Galaxy Note II and Galaxy Camera

Good news, storage junkies: Dropbox and Samsung have renewed their vows with a deal that'll provide 50GB of free storage for two years to owners of the new Galaxy Note II and Galaxy Camera. As you'd expect, this means the Dropbox app will be pre-installed, and it also ensures that users will have easier access to their media files. Before you get too excited, however, there's no guarantee that this well-intentioned promotion will pass muster with US carriers -- we've certainly seen a few hopes dashed in the past.

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50GB free Dropbox service confirmed for Samsung Galaxy Note II and Galaxy Camera originally appeared on Engadget on Thu, 30 Aug 2012 23:20:00 EDT. Please see our terms for use of feeds.

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Thursday, August 30, 2012

Bacterial cause found for skin condition rosacea

ScienceDaily (Aug. 28, 2012) ? Scientists are closer to establishing a definitive bacterial cause for the skin condition rosacea. This will allow more targeted, effective treatments to be developed for sufferers, according to a review published in the Journal of Medical Microbiology.

Rosacea is a common dermatological condition that causes reddening and inflammation of the skin mostly around the cheeks, nose and chin. In severe cases skin lesions may form and lead to disfigurement. Rosacea affects around 3% of the population -- usually fair-skinned females aged 30-50 and particularly those with weak immune systems. The condition is treated with a variety of antibiotics, even though there has never been a well-established bacterial cause.

A new review carried out by the National University of Ireland concludes that rosacea may be triggered by bacteria that live within tiny mites that reside in the skin.

The mite species Demodex folliculorum is worm-like in shape and usually lives harmlessly inside the pilosebaceous unit which surrounds hair follicles of the face. They are normal inhabitants of the face and increase in number with age and skin damage -- for example, following exposure to sunlight. The numbers of Demodex mites living in the skin of rosacea patients is higher than in normal individuals, which has previously suggested a possible role for the mites in initiating the condition.

More recently, the bacterium Bacillus oleronius was isolated from inside a Demodex mite and was found to produce molecules provoking an immune reaction in rosacea patients. Other studies have shown patients with varying types of rosacea react to the molecules produced by this bacterium -- exposing it as a likely trigger for the condition. What's more, this bacterium is sensitive to the antibiotics used to treat rosacea.

Dr Kevin Kavanagh who conducted the review explained, "The bacteria live in the digestive tracts of Demodex mites found on the face, in a mutually beneficial relationship. When the mites die, the bacteria are released and leak into surrounding skin tissues -- triggering tissue degradation and inflammation."

"Once the numbers of mites increase, so does the number of bacteria, making rosacea more likely to occur. Targeting these bacteria may be a useful way of treating and preventing this condition," said Dr Kavanagh. "Alternatively we could look at controlling the population of Demodex mites in the face.. Some pharmaceutical companies are already developing therapies to do this, which represents a novel way of preventing and reversing rosacea, which can be painful and embarrassing for many people."

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The above story is reprinted from materials provided by Society for General Microbiology, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

  1. Stanis?aw Jarmuda, Niamh O'Reilly, Ryszard ?aba, Oliwia Jakubowicz, Andrzej Szkaradkiewicz and Kevin Kavanagh. The potential role of Demodex folliculorum mites and bacteria in the induction of rosacea. Journal of Medical Microbiology, 2012 DOI: 10.1099/jmm.0.048090-0

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.


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Wednesday, August 29, 2012

Republican convention is in full-throated roar

Republican presidential nominee Mitt Romney hugs his wife Ann Romney on stage at the Republican National Convention in Tampa, Fla. on Tuesday, Aug. 28, 2012. (AP Photo/Jae C. Hong)

Republican presidential nominee Mitt Romney hugs his wife Ann Romney on stage at the Republican National Convention in Tampa, Fla. on Tuesday, Aug. 28, 2012. (AP Photo/Jae C. Hong)

President Obama runs to take the stage during campaign stop on the campus of Colorado State University in Fort Collins, Colo., on Tuesday, Aug. 28, 2012. Obama is making a two-day swing through the country to visit colleges. (AP Photo/David Zalubowski)

New Jersey Governor Chris Christie addresses the Republican National Convention in Tampa, Fla., on Tuesday, Aug. 28, 2012. (AP Photo/J. Scott Applewhite)

Ann Romney is greeted on stage by her husband Republican presidential nominee Mitt Romney after her speech to the Republican National Convention in Tampa, Fla. on Tuesday, Aug. 28, 2012. (AP Photo/J. Scott Applwhite)

Mary Pat Christie, left, wife of New Jersey Governor Chris Christie, speaks to Republican presidential nominee Mitt Romney's wife Ann during the governor's speech to the Republican National Convention in Tampa, Fla., on Tuesday, Aug. 28, 2012. (AP Photo/Charlie Neibergall)

TAMPA, Fla. (AP) ? The Republican National Convention is finally in full-throated roar, cheering presidential nominee Mitt Romney's name at every turn in a long-sought show of unity and mocking the man he is out to defeat in November.

A soft-sided portrayal of the Republican candidate as husband and father, painted by his wife on the stage in a direct appeal to women, combined with a parade of gleeful Obama-bashers Tuesday as the GOP seized its moment after days of worry about the hurricane that simultaneously roared ashore in Louisiana ? well out of sight of the gathering, and mostly out of mind for the night.

The convention's keynote speaker, the unpredictable New Jersey Gov. Chris Christie, issued a broad indictment of Democrats as "disciples of yesterday's politics" who "whistle a happy tune" while taking the country off a fiscal cliff.

"It's time to end this era of absentee leadership in the Oval Office and send real leaders to the White House," he said. "Mitt Romney will tell us the hard truths we need to hear to put us back on the path to growth and create good-paying private-sector jobs again in America."

Romney made his debut at the convention two days before his own speech, rousing the crowd into cheers as he took the stage briefly to share a kiss with his wife after she spoke. Ann Romney's prime-time speech was in large measure an outreach to female voters as she declared her husband "will not let us down" if elected president.

Her tone was intimate as she spoke about the struggles of working families: "If you listen carefully, you'll hear the women sighing a little bit more than the men. It's how it is, isn't it? It's the moms who always have to work a little harder, to make everything right."

Mrs. Romney's mission was clear. For all the hundreds of speeches he's given and the years he's spent reaching this moment, Romney remains largely inscrutable, a man in a business suit whose core remains a mystery to most of the nation. And he consistently lags behind President Barack Obama among women in polls.

Republicans have a little more than two months to change that and build upon his greatest perceived strength, as an economic fixer, in an election that by all indications is tight.

Elbowing in on the Republican's big week, Obama summoned a large campaign crowd of his own, 13,000 on the campus of Colorado State University in Fort Collins, Colo., and tried to convert their boos for the Republicans into Election Day results for him. "Don't boo, vote," Obama said when his reference to the GOP agenda brought derision from the crowd. "That's the best response. Vote and get some of your friends to vote."

Despite the respite from the preoccupation with Isaac, the storm continues to cast uncertainty into a convention that scrubbed the first day of events out of fear it would swipe Tampa, which it didn't. Any scenes of destruction along the Gulf Coast were sure to temper the celebratory tone, and further compression of the schedule was possible if the storm proved disastrous, making politicking unseemly.

The list of speakers is to be topped Wednesday night by Romney's running mate, Paul Ryan, before the candidate himself speaks Thursday night to bring down the curtain-closing balloons. Obama's Democratic National Convention follows next week in Charlotte, N.C.

Republicans uncorked the anti-Obama rhetoric from the outset Tuesday. The Democratic president has "never run a company," declared Reince Priebus, the Republican chairman. "He hasn't even run a garage sale or seen the inside of a lemonade stand." House Speaker John Boehner spoke of an America with "no government there to hold your hand. Just a dream and the desire to do better. President Obama doesn't get this. He can't fix the economy because he doesn't know how it was built."

Romney was affirmed as the nominee in a suspenseless roll call of state delegations. He received 2,061 votes to 190 for his nearest roll-call rival, Texas Rep. Ron Paul, a preordained victory sealed months ago when the former Massachusetts governor prevailed in a bruising series of primaries and caucuses. Rick Santorum, his most serious competitor at the height of the primary season, closed ranks Tuesday night, at least to a point. He slammed Obama for turning the American dream of freedom into a "nightmare of dependency" in a speech focused on welfare reform and mentioning Romney only at the end.

Paul, the iconoclastic libertarian who has a passionate following but never won a primary race, did not go so quietly, or at least his supporters didn't. They chanted and booed after the convention adopted rules they opposed but were powerless to block. "Shame on you," some of his supporters chanted from the floor.

Paul stopped short of a full endorsement of Romney and did not get a speaking slot. But his son, Kentucky Sen. Rand Paul, a tea party favorite, will address the convention Wednesday night.

Romney's nomination followed ratification of a party platform thoroughly shaped by conservatives and further to the right on abortion than the candidate himself. Nothing binds Romney to the document and presidents typically pay platforms little heed in office, except for the parts that echo their own agenda.

Obama campaigned in Iowa as well as Colorado on Tuesday as he set out on a campus tour in battleground states in hopes of boosting voter registration among college students.

Before departing the White House, he made a point of appearing before reporters to announce the government's latest steps to help those in the way of Isaac. He signed a declaration of emergency for Mississippi and ordered federal aid to supplement state and local storm response efforts in the state.

His allies did their best to counter Romney and the Republicans.

Los Angeles Mayor Antonio Villaraigosa, dismissing GOP attempts to woo Hispanic voters, said, "You can't just trot out a brown face or a Spanish surname and expect people are going to vote for your party or your candidate." He added, "This is a party with a platform that calls for the self-deportation of 11 million people."

Hispanics strongly favor Obama, according to public polls, and Romney and his party have been seeking to win a bigger share of their votes by emphasizing proposals to fix the economy rather than ease their positions on immigration.

Polls find the economy is overwhelmingly the dominant issue in the race and voters narrowly favor Romney to handle it. In an AP-GfK poll taken Aug. 16-20, some 48 percent of registered voters said they trust Romney more on economic issues, to 44 percent for Obama. However, a Washington Post-ABC News in the days immediately before the convention found that 61 percent of registered voters said Obama was more likable, while 27 percent said Romney.


Woodward reported from Washington. Associated Press writers Brian Bakst, Thomas Beaumont, Tamara Lush, Brendan Farrington, Julie Mazziotta, Steve Peoples, Kasie Hunt and Philip Elliott in Florida and Stephen Ohlemacher, Alicia A. Caldwell and Jennifer Agiesta in Washington contributed to this report.

Associated Press


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NASA releases amazing HD video of Curiosity Mars rover touchdown

Viewers can now watch a 1080p version of the touchdown of NASA's Curiosity Mars rover, the first spacecraft to record its landing on another planet.

By Associated Press / August 23, 2012

This is a full-resolution version of the NASA Curiosity rover descent to Mars, taken by the MARDI descent imager. As of August 20, all but a dozen 1600x1200 frames have been uploaded from the rover, and those missing were interpolated using thumbnail data. The result was applied a heavy noise reduction, color balance, and sharpening for best visibility.

Viewers can now relive the drama of the Curiosity rover's landing on Mars with a new video detailing the final moments of touchdown.

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Curiosity is the first spacecraft to record a landing on another planet. The U.S. space agency Thursday posted the video on its website, embedded with audio from mission control. It starts with the heat shield falling away. The ground grows larger in view as Curiosity is lowered by cables into an ancient Martian crater.

"Touchdown confirmed" is heard, followed by cheers.

The rover arrived on Aug. 5 to begin a two-year mission to examine whether the Martian environment was hospitable for microbial life.

NASA previously released a low-quality video of Curiosity's landing. The latest video is higher quality, but it's incomplete and is missing several frames.


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Monday, August 27, 2012

Almanac forecast: Wintry weather _ and mystery

LEWISTON, Maine (AP) ? The weather world is full of high-profile meteorologists like NBC's Al Roker and the Weather Channel's Jim Cantore. But the guy making the forecasts for the Farmers' Almanac is more like the man behind the curtain.

He's cloaked in mystery.

The publisher of the 196-year-old almanac, which goes on sale this week, takes great pains to protect the identity of its reclusive weather soothsayer, who operates under the pseudonym Caleb Weatherbee. Caleb's real name and hometown are a secret. And so is his age-old formula used for making long-term weather forecasts.

"It's part of the mystique, the almanac, the history," said Editor Peter Geiger of the current prognosticator, the almanac's seventh, who has been underground since starting the job in the 1980s.

Even just to speak to the forecaster, the almanac would agree only to an unrecorded phone call with the man from an undisclosed location.

The weather formula created by almanac founder David Young in 1818 was based on planetary positions, sunspots and lunar cycles. Since then, historical patterns, weather data and a computer have been added to the mix.

The mystery man's forecast for the coming winter suggests that people from the Great Lakes to northern New England should get out their long johns and dust off their snow shovels because it's going to be cold and snowy. It's also supposed to be wet and chilly in the Southeast, and milder for much of the rest of the nation.

In an election season, the almanac dubbed its forecast "a nation divided" because there's a dividing line where winter returns for much of the east, with milder weather west of the Great Lakes.

Scientists generally don't think too much of almanac's formula.

Ed O'Lenic, operations chief for NOAA's Climate Prediction Center, declined to knock the almanac's methodology but said sun spots and moon phases aren't used by modern-day meteorologists.

"I'm sure these people have good intentions but I would say that the current state of the science is light years beyond what it was 200 years ago," O'Lenic said from Maryland.

In this year's edition, the almanac's editors are contrite about failing to forecast record warmth last winter but they suggested readers should go easy on the publication ? and on Caleb ? because nobody forecast 80-degree weather in March that brought the ski season a rapid end in northern New England.

"Let's face it ? the weather was so wacky last year. It was so bizarre," said Sandi Duncan, managing editor, pointing out that NOAA and Accuweather also missed the mark.

Indeed, NOAA and Accuweather didn't project the extent of the warm winter.

"We missed it too, to put it bluntly," said Tom Kines, a meteorologist at Accuweather in State College, Pa. "It was a weird winter last year."

The Maine-based Farmers' Almanac is not to be confused with the New Hampshire-based Old Farmer's Almanac. Both issue annual forecasts, with the Old Farmer's Almanac scheduled for next month.

Geiger, who keeps a copy of Weatherbee's secret weather formula in a secure location, is quick to point out that there's more to the almanac than just weather forecasts. Hearkening to its old traditions, the folksy almanac features recipes, gardening tips, jokes, facts and trivia, and a guide to a simpler life.

For example, who knew that you could clean your toilet by pouring in Coca-Cola instead of harsh chemicals, or that putting a spoonful of vinegar in a pet's water dish keeps fleas at bay?

As for the weather, almanac readers say it's all good, clean fun.

"It's a fun publication to get and to read, to watch and see how accurate it is," said Wanda Monthey of Alexandria, Va. "It's a lot like a game."




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Opinion: Dodgers up ante in Battle for LA

New ownership group's willingness to spend should worry rival Angels

Image: Adrian GonzalezGetty Images

First baseman Adrian Gonzalez celebrates in the dugout after hitting a three-run home run in his first at-bat as a Dodger in the first inning against the Miami Marlins on Saturday night.



The Orange County Register

updated 1:14 a.m. ET Aug. 26, 2012

LOS ANGELES - Arte Moreno invested $250 million in December to get Albert Pujols.

Before Saturday, who would have thought that price was low-ball?

Had Guggenheim Baseball Management taken control of the Dodgers during last season instead of this one, Moreno, in the resultant, unavoidable bidding war for Pujols, might have lost everything up to and including his eyebrows.

Outspending the St. Louis Cardinals took some deep pockets. Outspending these guys would have taken some shallow oceans.

Click for related content

So, Angels fans, embrace your good luck today. After what the Dodgers' new owners just did ? bought, pretty much, the Boston Red Sox ? they almost certainly would have parted with the necessary millions to sign Pujols. Plus another $50 million or so, just to be safe.

These guys have financial clout the same way Melky Cabrera had pharmaceutical clout. To an offending degree.

"We're fortunate," Dodgers general manager Ned Colletti said, "to have the backing that we have here."

Fortunate? That's one way to describe possessing the wherewithal to drop more than a quarter of the billion dollars on an All-Star first baseman, a broken outfielder, a pitcher with six victories in his past 25 starts and Nick Punto.

Now, just imagine how plentiful things will be around here after the Dodgers sign their new television deal after the 2013 season.

If Moreno could sell images of the Angels to Fox Sports for $3 billion, the Guggenheim group might negotiate a TV contract that pays out in caviar made of plutonium spread on toast-points encrusted with diamonds.

"It's clear," Dodgers manager Don Mattingly announced. "We're just here to win."

Or spend more than the gross national product of Indonesia trying.

Hey, we're not whining, not bemoaning the lost art of player development or the newly found art ? at least locally ? of purchasing a pennant. If the Yankees can do it for generations, why can't the Angels and Dodgers do it for now?

When the Guggenheim guys took over the Dodgers in the spring ? price tag: $2.15 billion ? they promised to be aggressive in making home improvements and unafraid of investing the needed funds.

Asked about those claims Saturday, after his owners assumed 14 years and $262.5 million in contracts from the Red Sox, Mattingly had to admit, "Well, I didn't think it would be quite like this."

No one did. No one foresaw 53-year-old Magic Johnson leading a fast break that spews money. No one figured a guy named Mark Walter ? Guggenheim's CEO ? would be agreeing to purchase a $102.5-million outfielder (Carl Crawford) who, because of surgery, currently is incapable of picking up a baseball, never mind throwing the thing.

The Dodgers once built an empire on the backs of a homegrown infield. That was the old-fashioned way of operating, a blueprint as classic and quaint as a Dodger Dog.

Though they say grassroots baseball will remain the foundation, these Guggenheim guys also see no reason to wait around for the sprouts to appear.

The new Dodgers? They could be the first team in baseball history to field a solid gold second baseman.

"It is," Colletti said, "a different place now."

A few hours later, Dodger Stadium was an unglued place. Adrian Gonzalez, the main piece acquired from Boston, homered in his first at-bat, a three-run shot that was as well timed as a Cirque du Soleil routine and at least twice as theatric.

The Dodgers eventually won, 8-2, completing maybe the most dramatic day in baseball history that didn't include someone lifting the World Series trophy.

Gonzalez was born in San Diego, but he obviously understands Hollywood. After flying cross-country just to get here, what better way to continue establishing your new career path than by driving yourself home?

As the son of Mexican parents, Gonzalez would seem to be an ideal fit here, similar to how Fernando Valenzuela's presence once filled Chavez Ravine as sweetly as the sound of the Dodger Stadium organ.

"Wow," Johnson said. "I think we're going to get a different kind of mania going."

So this is what the National League West is now up against. This is what baseball is now up against. This is what the Angels are now up against.

Moreno used to reign over Frank McCourt, who had a paper fortune. The Dodgers' new owners have a paper fortune, too. It's green on one side, gray on the other and, when stacked real high, can buy enough potential and hope to maybe rescue an entire summer.

The rivalry between the Dodgers and Angels never has been more interesting than it is right now. Both teams are desperately pursuing the Southland's next World Series title, willing to pay whatever price ? literally ? is necessary.

It's a great time to be a baseball fan around here, whether you're L.A. or Anaheim, Tinsel Town or Disneyland.

And Gonzalez fit right in, even before that first at-bat. When he arrived at Dodger Stadium for Saturday's game, he did so in a T-shirt bearing the likeness of a cartoon character: Mickey Mouse.


More news
Loney a hit in Red Sox debut

James Loney hit a tying single in his Boston debut as the revamped Red Sox bounced back from a nine-player trade and a 12-inning loss to beat the Kansas City Royals 8-6 on Sunday.


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Thursday, August 23, 2012

On Carrying Water (Theagitator)

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Tuesday, August 21, 2012

Comments on The Draft African Union Convention on the - blog*spot

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On Zynga and Greater Fools (Ed Batista)


From James Temple in today's San Francisco Chronicle:

In early April, Zynga Chief Executive Officer Mark Pincus dumped 15 percent of his shares for about $198 million, in an unusual secondary stock offering that came almost two months before the official selling lockup for insiders ended. It turned out to be spectacular timing--at least for Pincus and other executives and early investors. They unloaded big portions of their holdings for $12 per share. By the end of July, after the social gaming company whiffed on second-quarter analyst expectations and sliced forecasts for the year roughly in half, the stock had dipped below $3...

Rank-and-file Zynga employees also feel they've missed out on riches. On the question-and-answer site Quora, anonymous users who said they were Zynga workers vented their frustrations over working long hours for years only to wind up with restricted stock that tumbled in value before their lock-up period ended.

"I worked 100 hour weeks," one wrote. "Week, after week, after week. I hated the management. I hated the culture, but we all knew the IPO was right around the corner, and once it came, as long as the s----- [sic] organization could keep it together for the lockout period, I'd have made bank, and in some way, that would have made my three and something miserable years there worth it."

As someone who's lived and worked in San Francisco for over two decades--including nearly six years as a Leadership Coach at Stanford's Graduate School of Business--I certainly know people who've spent untold hours at jobs they don't particularly enjoy in the hopes of realizing a big payday from an IPO or acquisition. That's not a choice I'd make, and it's not a life I'd want to live, but I realize that people may make that choice for any number of reasons, and I emphathize with those who've followed that path only to find their hopes dashed.

But in some cases employees seem to be praying that they make it into the castle with early investors?before the drawbridge is pulled up--while counting on acquirers or public investors to be the greater fools. Temple notes that shareholders have sued Zynga, claiming that the secondary offering constitutes insider trading and citing the "colossal losses" experienced by both non-executive employees and other public shareholders.

I'm appalled (although, sadly, not surprised) by the actions taken by Zynga's executives and early investors, but I can't quite bring myself to see all of the employees as victims here. At least some of them hated management, hated the culture, thought it was a shitty organization and were just hanging on until the IPO, when public investors--who knew even less about the company than the employees did--would unknowingly take the fall for everyone else. (You didn't even need to be an employee to have a dim view of the company: over the past year or so several of my MBA students at Stanford mentioned what they perceived as an unhealthy working environment at Zynga.)

I'm not suggesting that Zynga employees were seeking to mislead public investors, but I'm less empathetic than I might be otherwise. As Joseph Sternberg wrote just last week in the Wall Street Journal,?"The [greater-fool theory of investing] is more than a little dangerous, and plenty of people have lost a lot of money when they discovered they were the fool at the end of the chain."

Photo ? Paul Sakuma, Associated Press.


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Friday, August 17, 2012

Team uncovers link between hormone levels and risk for metabolic disease

Thursday, August 16, 2012

Working with a national team of researchers, a scientist from the Florida campus of The Scripps Research Institute has shown for the first time a link between low levels of a specific hormone and increased risk of metabolic disease in humans.

The study, published online ahead of print in The Journal of Clinical Endocrinology & Metabolism, focuses on the hormone adropin, which was previously identified by Scripps Research Associate Professor Andrew Butler's laboratory during an investigation of obese and insulin-resistant mice. Adropin is believed to play an important role in regulating glucose levels and fatty acid metabolism.

"The results of this clinical study suggest that low levels of adropin may be a factor increasing risk for developing metabolic disorders associated with obesity and insulin resistance, which could then lead to diseases such as type 2 diabetes," said Butler, who led the new study with Peter J. Havel, professor of molecular biosciences and nutrition at the University of California, Davis.

Approximately 47 million adults in the United States have metabolic syndrome, according to the American College of Cardiology. The National Institutes of Health defines metabolic syndrome as a group of risk factors, especially obesity and insulin resistance, that occur together and increase the risk for coronary artery disease, stroke, and type 2 diabetes.

Intriguing Results

In the new study, which involved 85 women and 45 men, Butler and his colleagues showed that obesity is associated with lower adropin levels. Lower adropin levels were also observed in individuals with a higher "metabolic syndrome risk factor" score, a score determined by measuring triglycerides, LDL cholesterol, HDL, glucose, blood pressure, and waist circumference.

The scientists also observed circulating adropin concentrations increased significantly at three and six months following gastric bypass surgery in morbidly obese patients. Interestingly, adropin levels returned to pre-surgical levels at 12 months after surgery.

Another surprising finding of the new study was that in people of normal weight, women had lower plasma adropin levels than men. In addition, obesity had a bigger negative effect on adropin levels in men. Interestingly, obesity in woman was also not associated with lower plasma adropin levels. The significance of the differences between men and woman is unknown at the moment.

"But the link between low levels of adropin and increased metabolic risk was observed in both sexes," Butler said. "The impact is there, irrespective of gender."

Adropin levels were also found in general to decrease with age?the decline was highest in those over 30 years of age. As with obesity, the aging effect appeared to be more pronounced in men.

Findings in Humans Mirror Preclinical Work

The new study is an important extension of earlier pre-clinical studies using animal models published in the July edition of Obesity. In that study, Butler and colleagues deleted the gene encoding adropin from mice. The scientists found that, while normal in appearance, adropin-deficient mice have insulin resistance and, when fed diets with a high fat content, develop a more severe impaired glucose tolerance (IGT). These findings suggest reduced insulin production and attenuated response to insulin, which are the defining features of type 2 diabetes. Importantly, mice having only one functional copy of the gene encoding adropin also exhibited increased propensity for developing impaired glucose tolerance with obesity. These findings provided important pre-clinical evidence evidence that low levels of adropin are associated with increased risk of developing type 2 diabetes.

In other studies, Butler's laboratory observed that obese mice exhibit dramatic reductions in circulating adropin levels, and that insulin resistance was reversed after injections with a synthetic form of adropin.

"The data from these studies provide strong evidence suggesting that low levels of adropin may be an indicator of risk for insulin resistance in obesity and, consequently, an increased risk for metabolic diseases, including type 2 diabetes," Butler said. "We see a lot of similarity between animal model data and the new human data?low adropin levels in humans are associated with a host of metabolic syndrome risk factors normally associated with obesity and insulin resistance."

Taken together, these studies suggest the possibility that therapeutics designed to boost the supply of adropin might be useful in fighting obesity and metabolic disease.


Scripps Research Institute:

Thanks to Scripps Research Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Romney: Never paid less than 13 percent in taxes

Republican presidential candidate, former Massachusetts Gov. Mitt Romney writes on a white board as he talks about Medicare during a news conference at Spartanburg International Airport, Thursday, Aug. 16, 2012, in Greer, S.C . (AP Photo/Evan Vucci)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney writes on a white board as he talks about Medicare during a news conference at Spartanburg International Airport, Thursday, Aug. 16, 2012, in Greer, S.C . (AP Photo/Evan Vucci)

President Barack Obama speaks at a campaign event, Wednesday, Aug. 15, 2012, in Davenport, Iowa, during a three day campaign bus tour through Iowa. (AP Photo/Carolyn Kaster)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney speaks with the media after arriving at Spartanburg International Airport, Thursday, Aug. 16, 2012, in Greer, S.C . (AP Photo/Evan Vucci)

Republican vice presidential candidate Rep. Paul Ryan, R-Wis. speaks at a campaign stop at Walsh University in North Canton, Ohio, Thursday, Aug. 16, 2012. (AP Photo/Phil Long)

Republican vice presidential candidate, Rep. Paul Ryan, R-Wis. gestures during a campaign stop at Walsh University in North Canton, Ohio, Thursday, Aug. 16, 2012. (AP Photo/Tribune Review, Justin Merriman ) PITTSBURGH OUT

GREER, S.C. (AP) ? Republican presidential contender Mitt Romney declared Thursday he has paid at least 13 percent of his income in federal taxes every year for the past decade, offering that new detail while still decrying a "small-minded" fascination over returns he will not release. President Barack Obama's campaign shot back in doubt: "Prove it."

Campaigning separately, Romney and running mate Paul Ryan also scrambled to explain their views on overhauling Medicare, the health care program relied on by millions of seniors.

Romney, the former company CEO, set up a whiteboard to make his case with a marker, while lawmaker Ryan resorted to congressional process language to explain why his budget plan includes the same $700 billion Medicare cut that he and Romney are assailing Obama for endorsing.

Essentially, Ryan said, he had to do it because Obama did it first.

Politically, both topics tie into major elements of the presidential race less than three months before the election: how well the candidates relate to the daily concerns and to the life circumstances of typical voters. Democrats are using the tax issue to raise doubts about Romney's trustworthiness ? or, as Republicans contend, to distract from a weak economic recovery under Obama.

Romney's comments in South Carolina ? at a news conference designed to focus on Medicare ? showed that he remains sensitive to criticism of his tax payments but still is determined to release no more than two years of records despite contrary advice from some prominent Republicans.

The Obama campaign has aired an ad that, without evidence, raises the prospect that Romney paid no taxes some years. Senate Majority Leader Harry Reid, D-Nev., elevated that suggestion by claiming, also without proof, that an anonymous source told him Romney had not paid taxes for 10 years.

"I did go back and look at my taxes and over the past 10 years I never paid less than 13 percent," Romney told reporters after he landed in South Carolina for a fundraising event. "I think the most recent year is 13.6 or something like that. So I paid taxes every single year."

Aides later said Romney meant to say 13.9 percent, the amount he already disclosed for his 2010 federal return.

On average, middle income families, those making from $50,000 to $75,000 a year, pay 12.8 percent of their income in federal taxes, according to the nonpartisan Joint Committee on Taxation. In 2010 and 2011, Romney made about $21 million a year.

Romney is able to keep his tax rate low because most of his income is from investments, which are generally taxed at a lower rate than wages. That type of legal tax figuring is something Obama has proposed changing, although his campaign notably said nothing about Romney's self-described tax rate itself.

Instead, the campaign targeted only Romney's truthfulness, refusing to accept his answer and pressuring him to release years of earlier tax returns.

"Prove it," said Obama spokeswoman Lis Smith. "Given Mitt Romney's secrecy about his returns, coupled with the revelations in just the one return we have seen to date and the inconsistencies between this one return and his other financial disclosures, he has forfeited the right to have us take him just at his word."

Reid's office said much the same. Romney demanded that Reid "put up" the name of his anonymous source.

"Given the challenges that America faces ? 23 million people out of work, Iran about to become nuclear, one out of six Americans in poverty ? the fascination with taxes I've paid I find to be very small-minded," Romney said.

Obama and Vice President Joe Biden have released their returns for the years since 2000. The Obamas paid 20.5 percent in federal income taxes in 2011.

Ryan, meanwhile, found himself doing his own explaining.

He and Romney have launched a new strategy this week of criticizing Obama for taking more than $700 billion in Medicare funds to help pay for his health care overhaul. Yet those same cuts are in a House Republican budget blueprint authored by Ryan.

A reporter pressed him on the issue during a stop at a hot dog restaurant in Warren, Ohio.

His explanation was that the Medicare cuts were part of the existing baseline budget, including the Obama health care law he opposes.

"It gets a little wonky, but it was already in the baseline," Ryan said. "We would never have done it in the first place."

Romney hadn't scheduled any public events but put together a last-minute news conference to explain the differences between his Medicare plan and Obama's.

"Which of these two do you think is better?" Romney asked as he stood under a glaring sun at an airport.

Romney says Obama has cut $716 billion from the Medicare trust fund to pay for his national health care overhaul, weakening the program. Those cuts, mostly from health providers and insurance plans instead of directly from beneficiaries, would decrease the cost of the entitlement program over time and extend the life of the trust fund.

Ryan's budget would make those same cuts, though he would use the savings differently.

Romney ? and Ryan, since joining the ticket ? insist the cuts must be restored. That could make Medicare go bankrupt more quickly. But Romney says other parts of his plan, including giving fewer benefits to wealthier retirees, would keep Medicare solvent in the long term.

Independent groups say he has not supplied enough details to determine whether he would significantly shore up Medicare in years to come.

Democratic strategists and party officials say that while they still expect the race to stay close through the fall, they sense a slight shift in Obama's favor over the past two weeks. However, they expect Romney to get a boost following his party's convention and say a dismal economic report right before the election could pull votes his way.

Obama spent the day in White House meetings save for a stop at Democratic National Committee headquarters. Romney is devoting most of this week, and much of next week, to raising money in non-competitive states including Alabama, South Carolina, Massachusetts, New York, Texas, Louisiana and New Mexico.


Steve Peoples reported from Warren, Ohio. Associated Press writers Ben Feller, Stephen Ohlemacher, Kasie Hunt, Matthew Daly and Julie Pace contributed from Washington.

Associated Press


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Ryan on Medicare cut: Obama did it first

WARREN, Ohio (AP) ? Republican vice presidential contender Paul Ryan says he never would have included a $700 billion Medicare cut in his budget if President Barack Obama hadn't done it first.

"He put those cuts there," Ryan said Thursday, responding to a reporter's question while eating a hot dog in a restaurant. "We would never have done it in the first place."

Medicare, the health care program for tens of millions of seniors, has become a key issue in the race for the White House.

The Wisconsin congressman is perhaps best known for authoring a controversial budget plan that would transform Medicare into a voucher-like system. He and Romney say the change is needed to preserve the popular program for future generations.

The Republican candidates have launched a new strategy recently to criticize Obama for taking more than $700 billion in Medicare funds to help pay for his health care overhaul.

"The president was talking about Medicare yesterday. I'm excited about this," Ryan said during a morning campaign stop in North Canton. "This is a debate we want to have, this is a debate we need to have and this is a debate we're going to win."

But Ryan did not mention that his own budget proposal included the same cut. A reporter pressed him on the issue during an impromptu stop at a local hot dog restaurant.

Ryan pointed out that he voted to repeal the president's health care law, which would have repealed the Medicare cut. The Senate did not take up the bill.


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Wednesday, August 15, 2012

Florida tea party favorite appears to take down 12-term GOP politician

Twelve-term Rep. Cliff Stearns trails his Republican primary opponent in Florida with 100 percent of precincts reporting.

Tea partyer Ted Yoho, a veterinarian and political newcomer, leads Stearns by 829 votes in a shocking upset, the Associated Press reported. Redistricting forced Stearns into a geographically larger, newly drawn district stretching north and west of his old territory, into Florida's panhandle.

One of Stearns' opponents, Clay County Clerk of Courts James Jett, alleged in March that Stearns had attempted to bribe him out of the race through a middleman. A Stearns spokesman denied the accusation. Jett ranks fourth in the unexpectedly crowded primary with 14 percent.

The winner of tea-party straw polls in Gainesville, Gilchrist and Lake City, Yoho ran a TV ad comparing career politicians to pigs in slop, promising new leadership and a repeal of "Obamacare." He recorded a YouTube video with a George W. Bush impersonator in which they bemoaned the Obama administration.

If results hold, Stearns will exit Congress after serving for 24 years. He made headlines as top Republican on the House Energy and Commerce Oversight and Investigations subcommittee with investigations into solar-panel maker Solyndra and steroid use in pro wrestling.

Get more pure politics at ABC and a lighter take on the news at

Also Read


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Samsung Galaxy Note 10.1 cases and keyboard dock eyes-on


The Galaxy Note 10.1 is now good and official stateside, and you know that means Samsung has some new accessories to shill. On hand at Lincoln Center were leather cases in a variety of colors (including white, orange and brown) along with versions that mimic the flip covers for the original Galaxy Note and the Galaxy S III -- the difference being that they don't replace the Note 10.1's backing, as that's not removable. Samsung also had a keyboard case on display, though so far we've yet to see more details. For now, you'll have to settle for our eyes-on photos below.

Update: Samsung told us many of the cases we saw today are not yet available, but it confirmed $50 a Book Cover case for the Note 10.1 in white and grey.

Zach Honig contributed to this report.

Filed under:

Samsung Galaxy Note 10.1 cases and keyboard dock eyes-on originally appeared on Engadget on Wed, 15 Aug 2012 13:29:00 EDT. Please see our terms for use of feeds.

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Iran rescues two quake survivors

Two people on Tuesday were pulled alive from the rubble of weekend quakes the destroyed villages in Iran's northwest, state media reported -- days after officials called a halt to rescue operations.

The two were plucked from the smashed remains of their home after being detected by search dogs, IRIB state television and the official IRNA news agency reported, citing regional emergency service workers.

IRNA said the pair, both in good health, were saved in a village near the town of Varzaqan, northeast of the city of Tabriz.

The hamlet was one of hundreds decimated by Saturday's twin quakes measuring 6.4 and 6.3 on the moment magnitude scale that killed 306 people and injured 3,000 others, according to an official toll.

The pair were rescued two days after Iranian Interior Minister Moustafa Mohammad-Najjar and his aide in charge of disaster management, Hossein Ghadami, declared a halt to rescue operations.

The officials had said there were no more survivors to be found.

Separately, the Fars news agency reported that an unspecified number of bodies were recovered on Tuesday, including that of a 27-year-old woman in the village.

Some officials and members of the Iranian public have criticised the official reaction to the earthquake, while others praised the rapid response of emergency services.

Iran's Red Crescent notably said it had refused offers of help from countries including Germany, Armenia, Turkey and Taiwan.

But Vice President Mohammad Reza Rahimi contradicted that on Monday by saying that, "under the current circumstances, (Iran) is now prepared to accept help from other countries for quake victims," IRNA reported.

The United States said it had also offered assistance but had received no reply from Iran, with which it has no direct diplomatic ties.


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Clarksvillain Roller Girls to hold Pool Tournament benefit for the ...


Clarksvillain Roller GirlsClarksville, TN ? On Friday, August 17th, the Clarksvillain Roller Girls will be hosting a 9-ball Billiards Tournament at Highballers Billiards Club & Sports Bar. Sign ups are from 6:00pm to 7:00pm with no late sign ups, with a $20.00 buy in.

There will be a cash prize for the winner, with portions of the buy in benefiting both the Clarksvillain Roller Girls and the Wounded Warrior Project.

Highballers Billiards Club & Sports Bar is located at 2092 Ashland City Road.

Come on out, meet the Villains, and support local roller derby!

Clarksvillain Roller Girls will be hosting a 9-ball Billiards Tournament at Highballers Billiards Club & Sports Bar




Ashland City Road, Clarksvillain Roller Girls, Clarksville TN, ighballers Billiards Club and Sports Bar, Pool Tournament, Wounded Warrior Project

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Monday, August 13, 2012

squidoo - Things to consider when buying a circular saw

It is essential to buy the right circular saw as they last for quite a while, from 10 to even 20 years. It is the main reason why you should consider several things before actually purchasing a circular saw.

Style Circular saws are available in two main styles. The first one of them is the worm-drive style, where the blade is positioned to the left, reason why it is highly appreciated by those who are right-handed. Although this saw style is heavier, it is a more powerful one with more torque compared to the other one, the sidewinder.

The second saw style is the sidewinder, which is most probably the most common style, where the blade (with a high handle) is positioned on the right side of the saw. This saw style is lighter and cheaper and can also spin faster as compared to the worm-drive style. Sellers generally consider sidewinders a better option as compared to the worm-drive.

Blade Size In most cases, these saws are classified according to the diameter of the blade. The 7 ? inch blade is the most popular one and can cut materials of 3 inch wide, with several blade options for different substances.

Power Amperage is the term which defines the power of the saw. Usually, the normal power is 15 amps, but occasional use of the saw do not require a power of over 10-12 amps.

Ergonomics For people who are not familiar with various saw components, most sidewinder circular saws look pretty much the same. The differences in terms of ergonomics can be figured out only if the saw is picked up and measured how they actually feel like. Thus, it is important to visit a tool supplier or DIY store to check out the saws by measuring them in your hands.

It is important for the saw to be well balanced and to have a weight that allows you to properly handle it. Also check you are fully comfortable with the visibility and components of the blade.

Cordless or Corded In the lack of electrical outlets the cordless ones are the perfect option. If you are going to work in a larger workshop it is preferable to have an extension cord (or even two). Still, keep in mind that corded saws are considerably more powerful than the cordless ones. Thus, it is recommended to go with a corded saw that includes a longer cord.

Blades New saws are sold in most cases with a multi-purpose wood cutting blade which is tipped with carbide. Based on the projects you are going to use the saw, this could be more than enough for it. Different blade options are also available in case you need to cut tile, concrete, wood and metal. If the saw is going to be used for several cutting projects, it is preferable to select a high tooth count blade.

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